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RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations  

2012-04-25 20:36:00|  分类: R、SVG&GNUPlot画 |  标签: |举报 |字号 订阅

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Abstract (provisional)

Visualization and analysis of molecular networks are both central to systems biology. However, there still exists a large technological gap between them, especially when assessing multiple network levels or hierarchies. Here we present RedeR, an R/Bioconductor package combined with a Java core engine for representing modular networks. The functionality of RedeR is demonstrated in two different scenarios: hierarchical and modular organization in gene co-expression networks and nested structures in time-course gene expression subnetworks. Our results demonstrate RedeR as a new framework to deal with the multiple network levels that are inherent to complex biological systems. RedeR is available from http://bioconductor.org/packages/release/bioc/html/RedeR.html

Mauro AA Castro, Xin Wang, Michael NC Fletcher, Kerstin B Meyer and Florian Markowetz

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Genome Biology 2012, 13:R29 doi:10.1186/gb-2012-13-4-r29

Published: 24 April 2012

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

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