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Mauve Multiple Genome Alignment Software  

2010-12-23 10:01:08|  分类: 生物信息分析 |  标签: |举报 |字号 订阅

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About Mauve

Mauve is a system for efficiently constructing multiple genome alignments in the presence of large-scale evolutionary events such as rearrangement and inversion. Multiple genome alignment provides a basis for research into comparative genomics and the study of evolutionary dynamics.  Aligning whole genomes is a fundamentally different problem than aligning short sequences.

Mauve has been developed with the idea that a multiple genome aligner should require only modest computational resources. It employs algorithmic techniques that scale well in the amount of sequence being aligned. For example, a pair of Y. pestis genomes can be aligned in under a minute, while a group of 9 divergent Enterobacterial genomes can be aligned in a few hours.

Download Mauve

Mauve is distributed free-of-charge for Windows, Mac OS X, and Linux.  Please visit the download section to obtain a copy of Mauve.

Mauve Support

After installing Mauve, we suggest subscribing to the mauve-announce and mauve-users mailing lists. The mauve-announce mailing list is a low-traffic list on which we make announcements about new software versions with bug fixes and new features. The mauve-users list is a general discussion forum for users of the Mauve software to communicate with each other and resolve usage issues.

Prior to posting a usage-related question about Mauve to the mauve-users list, please search the mauve-users list archives

Other software based on Mauve

Various analysis tools have been developed to make inference on the basis of Mauve genome alignments.  We maintain a listing of Mauve-based tools

Citing Mauve in a Publication

If you use the progressiveMauve algorithm, please cite:

Aaron E. Darling, Bob Mau, and Nicole T. Perna. 2010.  progressiveMauve: Multiple Genome Alignment with Gene Gain, Loss, and Rearrangement.  PLoS One.  5(6):e11147.

The original Mauve paper was published as: 

Aaron C.E. Darling, Bob Mau, Frederick R. Blatter, and Nicole T. Perna.  2004.  Mauve: multiple alignment of conserved genomic sequence with rearrangements.  Genome Research.  14(7):1394-1403.
The paper is now freely available from the Genome Research website.

Screenshots of Mauve

These are screenshots of Mauve 2.0 visualizing an alignment of nine Yersinia genomes:

Mauve 2.0 visualizing rearrangements in nine Yersinia genomes     Mauve 2.0 showing Yersinia in backbone color mode
 

Mauve 2.0 showing the conserved hemolysin gene in Yersinia    The Mauve 2.0 genome annotation search interface

 

Last Updated ( Thursday, 28 October 2010 )
LINKS TO:http://gel.ahabs.wisc.edu/mauve/
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